Safety of highdose iron sucrose infusion in hospitalized patients with chronic kidney disease. Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. Where C= concentration of elemental iron (mg/ml) in the product being used: Data from Ferrlecit postmarketing spontaneous reports indicate that individual doses exceeding 125 mg may be associated with a higher incidence and/or severity of adverse events, Adult Patients with Hemodialysis Dependent-Chronic Kidney Disease (HDD-CKD), Adult Patients with Non-Dialysis Dependent-Chronic Kidney Disease (NDD-CKD), WARNING: RISK FOR SERIOUS HYPERSENSITIVITY/ANAPHYLAXIS REACTIONS, Iron Deficiency and Anemia- signs and therapeutic options. Total dose iron infusion: safety and efficacy in predialysis patients. 3) Bayraktar UD, Bayraktar S. (2010) Treatment of iron deficiency anemia associated with gastrointestinal tract diseases. Administer Injectafer intravenously, either as an undiluted slow intravenous push or by infusion. Venofer must only be administered intravenously either by slow injection or by infusion. rabeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Applies only to oral form of both agents. Copyright 2014 - 2023 The Calculator .CO |All Rights Reserved|Terms and Conditions of Use, Intravenous iron-dextran: therapeutic and experimental possibilities, Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations, Treatment of iron deficiency anemia associated with gastrointestinal tract diseases, Diagnosis and management of iron deficiency anaemia: a clinical update. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. Applies to didanosine chewable tablets and powder for oral solution; administer 2 hr before or several hours after didanosine oral solution or chewable tablet administration. Privacy Policy, Use 500 mg for adults and children 35 kg; use 15 mg/kg if <35 kg. Modify Therapy/Monitor Closely. 2010; 193(9):525-32. The dosing for iron replacement treatment in pediatric patients with NDD-CKD or PDDCKD has not - been established. UpToDate. iron sucrose decreases levels of ofloxacin by inhibition of GI absorption. Intermediate calculations: -Blood volume (dL) = [65 (mL/kg) x body weight (kg)] / 100 (mL/dL) -Hgb deficit (g/dL) = 14.0 - patient hgb conc. Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. Use Caution/Monitor. There are physiological variation in iron reserves such as the decrease during menstruation period. in the colostrum of 10 iron deficient breastfeeding women who were 2 to 3 days postpartum and received a single dose of 100 mg of intravenous iron . Iron stores 500 mg for body weight greater than or equal to 35 kg (77 lbs) and 15 mg/kg for body weight less than 35 kg. The usual total treatment course of Venofer is 1000 mg. Venofer treatment may be repeated if iron deficiency reoccurs. Applies only to oral form of both agents. Applies only to oral form of both agents. Assure stable intravenous access to avoid extravasation. Applies only to oral form of both agents. Applies only to oral form of both agents. calcium gluconate decreases levels of iron sucrose by inhibition of GI absorption. Applies only to oral form of both agents. however iron sucrose requires multiple small intermittent doses over days to weeks. Applies only to oral form of both agents. Serious - Use Alternative (1)iron sucrose decreases levels of tetracycline by inhibition of GI absorption. Use Caution/Monitor. Manage and view all your plans together even plans in different states. iron sucrose, benazepril. Minor/Significance Unknown. iron sucrose will decrease the level or effect of sarecycline by inhibition of GI absorption. Monitor Closely (1)trientine, iron sucrose. Divide the calculated dose by the patient's weight (IBW if BMI >30, or actual body weight (ABW) if BMI30) to ensure it does NOT exceed 20mg/kg. All adult and pediatric patients receiving Venofer require periodic monitoring of hematologic and iron parameters (hemoglobin, hematocrit, serum ferritin and transferrin saturation). Applies only to oral form of both agents. Each mL contains 20 mg of elemental iron. Applies only to oral form of both agents. The factor 2.4 comes about from the calculation that the total iron content of hemoglobin is 0.34%, the blood volume accounts for 7% . Use Caution/Monitor. Separate by at least 4 hours. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. 300-500 mg Iron Sucrose in NS 250 mL administered over three (3) hours; may repeat as needed in 3-7 days to reach 1 gm. Calcs that help predict probability of a disease, Subcategory of 'Diagnosis' designed to be very sensitive, Disease is diagnosed: prognosticate to guide treatment. Avoid or Use Alternate Drug. Monitor Closely (1)pantoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Medscape Education, Improving Quality of Care in Patients With Iron Deficiency Anemia and Inflammatory Bowel Disease, 2010feosol-carbonyl-fe-icar-c-carbonyl-iron-342171Drugs, encoded search term (iron sucrose (Venofer)) and iron sucrose (Venofer), Use of High-Dose Iron in Dialysis in US Tracks PIVOTAL Trial, FDA Watch List Adds Drugs With Anaphylaxis, Herpes, Fetal Death Risk, Dialysis Industry Mergers: Profits Rise as Patient Outcomes Worsen, Hematology-Oncology Guidelines: 2017 Midyear Review. Venofer (iron sucrose injection, USP) is a brown, sterile, aqueous, complex of polynuclear iron (III)- . Iron stores are input as default 500 mg on the assumption that the patient weight is greater or equal to 35 kg (77 lbs). Applies only to oral form of both agents. Parenteral iron product is iron sucrose (C = 20 mg elemental iron/mL). Monitor Closely (1)didanosine will decrease the level or effect of iron sucrose by increasing gastric pH. Applies only to oral form of both agents. Do not double the dose to catch up. iron sucrose will decrease the level or effect of omadacycline by inhibition of GI absorption. Dosing: (a) Divide calculated total cumulate dose . For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. https://www.uptodate.com/ (Requires subscription). Each costs about $0.46 to $0.55 per mg of iron. Iron sucrose (Venofer) 100 mg/5 mL vial 200 - 300 mg given every 3-7 days 300 mg doses are given over 90 minutes 500 mg/dose. 1. Applies only to oral form of both agents. ANNA J. Administer Venofer early during the dialysis session (generally within the first hour). Applies only to oral form of both agents. Use Caution/Monitor. Use Caution/Monitor. Give each dose as 15 mg/kg body weight for a total cumulative dose not to exceed 1500 mg of iron per course. Use Caution/Monitor. In this study and another study evaluating a single intravenous dose of iron sucrose containing 500-700 mg of iron in 26 anemic patients on erythropoietin therapy (23 female, 3 male; age range 16-60), approximately 5% of the iron was . This site complies with the HONcode standard for trust- worthy health information: verify here. Sodium ferric gluconate (Ferrlecit) 62.5 mg . Use (s): Iron deficiency anemia in patients with chronic kidney disease (CKD) INFED- iron dextran injection [Package insert], Hemoglobin iron deficit (mg) = weight (kg) x (14 - Hgb) x (2.145) Note: Hbg (current hemoglobin level) units: (g/dL) Alternatively: Volume of product required (mL) = [weight (kg) x (14 - Hgb) x (2.145)] / C Where C= concentration of elemental iron (mg/ml) in the product being used: Iron dextran: 50 mg/mL. We first individually analyzed 5 clinical studies, averaging the total iron deficit across all patients utilizing a . Maximum single dose of iron sucrose to be given at a time in Non-dialysis CKD patients is 500 mg but with limited experience. Formula for calculating the required dose of iron sucrose 1. Each mL contains 20 mg of elemental . IDA diagnosis is based on full blood examination and on the serum ferritin level. Applies only to oral form of both agents. Untreated IDA in pregnancy is associated with adverse maternal outcomes such as post-partum anemia. Canada residents can call a provincial poison control center. These adverse reactions have occurred up to 30 minutes after the administration of Venofer injection. ------------------------------------------------------------------------- Iron Dextran Complex [ Infed ] Elemental iron: 50 mg of elemental iron per mL [2 mL] [package insert] BOXED WARNING: WARNING: RISK FOR ANAPHYLACTIC-TYPE REACTIONS Anaphylactic-type reactions, including fatalities, have followed the parenteral administration of iron dextran injection. Most adults require a cumulative dose of elemental iron of at least 1 g. Iron replenishment is usually doneintravenously, via iron-dextran, iron sucrose or iron carboxymaltose. Minor/Significance Unknown. Prescribing and dispensing information For iron sucrose A complex of ferric hydroxide with sucrose containing 2% (20 mg/mL) of iron. This drug is available at the lowest co-pay. Minor (2)calcium citrate decreases levels of iron sucrose by inhibition of GI absorption. [. Steps on how to print your input & results: 1. Iron Sucrose [ Venofer ] Elemental iron: 20 mg/mL (2.5 mL, 5 mL, 10 mL) Solution, Intravenous [preservative free]: [package insert] INDICATIONS: Venofer is an iron replacement product indicated for the treatment of iron deficiency anemia in patients with chronic kidney disease (CKD). Pediatric Patients: The most common adverse reactions (2%) are headache, respiratory tract viral infection, peritonitis, vomiting, pyrexia, dizziness, cough, nausea, arteriovenous fistula thrombosis, hypotension and hypertension. Venofer treatment may be repeated if iron deficiency reoccurs. 1000 mg. 20 MINUTES. A target haemoglobin value is also input so iron deficit can be determined according to a specified individual target. Creating an account is free and takes less than 1 minute. 2010niferex-hytinic-polysaccharide-iron-342160Drugs, You are being redirected to Applies only to oral form of both agents. Calculosaurus | Medical calculators for obstetrics and gynaecology Use the menu to browse through our clinical calculators. Applies only to oral form of both agents. Separate dosing of tetracyclines from these products. Monitor Closely (1)iron sucrose decreases levels of liothyronine by inhibition of GI absorption. This iron deficiency calculator determines the iron deficit based on patient weight, hemoglobin and iron stores to prepare for iron replacement. iron sucrose decreases levels of ciprofloxacin by inhibition of GI absorption. Adults and Children over 15 kg (33 lbs): Dose (mL) = 0.0442 (Desired Hb - Observed Hb) x LBW + (0.26 x LBW), Desired Hb = the target Hb in g/dl. Assessing new treatment options. Monitor Closely (1)rabeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Minor/Significance Unknown.iron sucrose increases levels of calcium chloride by enhancing GI absorption. *Repeat dose if iron deficiency anemia reoccurs. Applies only to oral form of both agents. Applies only to oral form of both agents. Comparable efficacy to that of IV iron sucrose. Deferoxamine chelates iron. Venofer has not been studied in patients younger than 2 years old. HOW TO USE: This medication is given by injection into a vein as directed by your doctor. Chandler G, Harchowel J, Macdougall I. Mode of Administration: Administer Venofer only intravenously by slow injection or by infusion. FOR PATIENTS WEIGHING LESS THAN 50 kg: Administer Monoferric as 20 mg/kg actual body weight by intravenous infusion 20 minutes . pantoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. If no signs or symptoms of anaphylactic-type reactions follow the test dose, administer the full therapeutic INFeD dose. Oral and parenteral products - see background option for oral products. This health tool computes the iron deficit based on patient parameters and the Ganzoni formula. iron sucrose increases levels of calcium citrate by enhancing GI absorption. Recommended Treatment Regimen Using IV Iron Sucrose for Initial Repletion in Children With Iron Deficiency Anemia. Nutr Clin Pract. Intravenous (IV) iron products (use in adults) Dosing information in this table is for adults and includes some dosing recommendations not listed in the approved product information. Uses for Iron Sucrose A patients lean body weight (or actual body weight if less than lean body weight) should be utilized when determining dosage. Intermediate calculations: -Blood volume (dL) = [65 (mL/kg) x body weight (kg)] / 100 (mL/dL) -Hgb deficit (g/dL) = 14.0 - patient hemoglobin conc. Applies only to oral form of both agents. famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Diluted with 0.9% Sodium Chloride Injection at concentrations of 1 to 2 mg/mL, 2 doses of 300 mg/250 mL over 1.5 hrsplus1 dose of 400 mg/250 mL over 2.5 hrs.
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